Synthesis and properties of a biocompatible analogue for β-turn protein structural motifs based on 5-amino-3-pentynoic acid

Article abstract of DOI:10.1016/0040-4039(96)01514-6

5-Amino-3-pentynoic acid, a new 'lightly' constrained amino acid surrogate for glycylglycine and model for dipeptide homologues was prepared from propargylamino and methods were devised for its incorporation into linear oligopeptides through both C- and N-terminal extension.