Highly diastereoselective reduction of enantiomerically pure aziridino ketones

Article abstract of DOI:10.1016/0040-4020(96)00703-X

Various enantiomerically pure aziridino ketones were prepared from the corresponding secondary alcohols by Swern oxidation. Those configurationally stable α-amino ketones were stereoselectively reduced by L-Selectride to provide the corresponding alcohol with high diastereoselectivities and chemical yields.