Regiochemistry in addition of Grignard reagents to N,N'-dibenzylated 2-purinones

DOI: 10.1016/0040-4020(96)00779-X

Source and publish data:

Tetrahedron p. 12979 - 12992 (1996)

Update date:2022-08-03

Topics:

Authors:

Andresen, Geir

Gundersen, Lise-Lotte

Rise, Frode

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(96)00779-X

1,3-, 1,7-, 1,9- and 3,7-dibenzylpurin-2-one form stable adducts when reacted with Grignard reagents. Reaction took place in the purine 6- or 8-position, and substantial differences in the regiochemical outcome of the reactions were found among the isomers. Several new classes of purinones are described here for the first time. The structure elucidations of the products were accomplished by HETCOR, COLOC, GA-HMQC and GA-HMBC NMR spectroscopy.

Full text of DOI:10.1016/0040-4020(96)00779-X

Products guided by the article

Product name:2H-Purin-2-one, 1,3,6,9-tetrahydro-6-phenyl-1,9-bis(phenylmethyl)-

Cas No:182862-65-3

R&D Labs maybe for 182862-65-3

Advanced Biotech

Contact:+1-973-357-0577

Address:10 Taft Rd.
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

website:http://www.jlpharms.com

Contact:86-571-86982636

Address:Rm A606, Fuyi Center, jianqiao street
Nanjing Yuance Industry&Trade Co., Ltd.

website:http://www.njyuance.cn/

Contact:+86-25-85439097

Address:B1702, Aoti Bldg, No. 130, Aoti Avenue, Nanjing, China
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
ALPHA PHARMACEUTICAL CO，LTD JIANGSU

Contact:+86-527-84829968,+86-527-84829998

Address:suqian city

Relevant to this article

Mechanistic aspects of the synthesis of 3-aminopyrroles from substituted 2-methyl-1,2-thiazolium salts or 3-amino-thioacrylamides

Doi:10.1039/p19960002339
(1996)
First diastereoselective synthesis of methyl caffeoyl- and feruloyl-muco-quinates

Doi:10.1039/c2ob25124h
(2012)
Zinc(II) perchlorate hexahydrate catalyzed opening of epoxide ring by amines: Applications to synthesis of (RS)/(R)-propranolols and (RS)/(R)/(S)-naftopidils

Doi:10.1021/jo062674j
(2007)
One- and two-metal ion catalysis of the hydrolysis of adenosine 3'-alkyl phosphate esters. Models for one- and two-metal ion catalysis of RNA hydrolysis

Doi:10.1021/ja9607300
(1996)
High-affinity α-aminobutyric acid A/benzodiazepine ligands: Synthesis and structure - Activity relationship studies of a new series of tetracyclic imidazoquinoxalines

Doi:10.1021/jm960401i
(1996)
γ-Silicon Stabilization of Carbonium Ions in Solvolysis. 2. Solvolysis of 4-(Trimethylsilyl)-2-butyl p-Bromobenzenesulfonates

Doi:10.1021/ja00237a027
(1987)

Article Doi