Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes

Article abstract of DOI:10.1016/0040-4039(96)01398-6

Deprotonation of fluoroarenes carrying chlorine or bromine as additional substituents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide.