Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V 1A receptor

DOI: 10.1016/j.bmc.2005.10.035

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1827 - 1837 (2006)

Update date:2022-07-29

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Authors:

Shimada, Yoshiaki

Taniguchi, Nobuaki

Matsuhisa, Akira

Akane, Hiroaki

Kawano, Noriyuki

Suzuki, Takeshi

Tobe, Takahiko

Kakefuda, Akio

Yatsu, Takeyuki

Tahara, Atsuo

Tomura, Yuichi

Kusayama, Toshiyuki

Wada, Koh-Ichi

Tsukada, Junko

Orita, Masaya

Tsunoda, Takashi

Tanaka, Akihiro

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Article abstract of DOI:10.1016/j.bmc.2005.10.035

To find potent and selective antagonists of the arginine vasopressin (AVP) V_1A receptor, optimization studies of compounds structurally related to (Z)-N-{4′-[(4,4-difluoro-5-carbamoylmethylidene-2,3,4,5-tetrahydro-1H- 1-benzazepin-1-yl)carbonyl

Full text of DOI:10.1016/j.bmc.2005.10.035

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Product name:Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-5H-1-benzazepin-5-yl idene]-, methyl ester, (2Z)-

Cas No:183171-60-0

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