A free radical approach to functionalization of phosphonates utilizing novel 2- and 3-phosphonyl radicals

Article abstract of DOI:10.1016/0040-4020(96)00820-4

A general method for the phosphonyl C₂-C₃-C bond formation under the free radical, reductive conditions is described. The new approach is based on the synthesis of novel 2- and 3-phosphonyl radicals 6, 9 derived from the corresponding 2- and 3-halo (X = Cl, Br, I) substituted phosphonates 7, 10 and their reaction with alkenes 4. Functionalized phosphonates 5, 8 possessing the 2+2 and 3+2 elongated carbon chain were obtained in 24-73% yields.