Chiral phosphine oxides and chiral esters in stereoselective intermolecular acylation reactions of phosphine oxides

Article abstract of DOI:10.1016/0040-4039(96)01612-7

Single diastereomers of β-keto phosphine oxides have been generated from intermolecular acylation of phosphine oxides using either chiral esters or chiral phosphine oxides. In some cases, reduction of the ketone products was not affected by the presence of extra chiral centres. Some mechanistic points of interest in the acylation reactions are discussed.