Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function

Article abstract of DOI:10.1021/ja9615841

Trapoxin, a cyclotetrapeptide isolated from the fungus Helicoma ambiens, profoundly affects mammalian cell growth and morphology. In this paper, we describe syntheses of trapoxin, [³H]trapoxin, and K-trap, a trapoxin-based affinity reagent. The