Use of 19F NMR spectroscopy to evaluate reactions in solid phase organic synthesis

Article abstract of DOI:10.1016/0040-4039(96)01704-2

Gel-phase ¹⁹F NMR spectroscopy has been used to characterize products from a variety of reactions of fluorinated aromatics linked to a TentaGel resin. High quality spectra were obtained in a few minutes using an ordinary NMR spectometer, and the ¹⁹F chemical shifts of the support-bound compounds closely matched those of soluble references. In addition, substantial chemical shift differences were obtained for almost all of the synthetic transformations, illustrating the potential of ¹⁹F NMR for rapid monitoring of reactions in solid-phase organic synthesis.