7,10-Bis(2-mercapto-2-methyl)propyl-7,10-diazapalmitic acid: A novel, N2S2 ligand for technetium-99m

Article abstract of DOI:10.1016/0960-894X(96)00440-4

7,10-Bis(2-mercapto-2-methyl)propyl-7,10-diazapalmitic acid (7) was synthesized and evaluated as a new ligand for technetium-99m (^99mTc). The title fatty acid analog, an achiral, bis(aminoethanethiol) derivative in which the amines are tertiary, gave a stable complex with ^99mTc. The biodistribution of ^99mTc-labeled 7 in rats is reported.