Tetrahedron p. 10983 - 10992 (1997)
Update date:2022-08-02
Topics:
Maligres, Peter E.
Houpis, Ioannis
Rossen, Kai
Molina, Audrey
Sager, Jess
Upadhyay, Veena
Wells, Kenneth M.
Reamer, Robert A.
Lynch, Joseph E.
Askin, David
Volante
Reider, Paul J.
Houghton, Peter
The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall yield from isonipecotic acid 3.
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Doi:10.1021/om960760b
(1997)Doi:10.1016/j.tetasy.2011.08.015
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(2000)Doi:10.1248/cpb.50.1362
(2002)Doi:10.1021/jo9616062
(1997)
