Synthesis of the orally active spiroindoline-based Growth Hormone Secretagogue, MK-677

DOI: 10.1016/S0040-4020(97)00359-1

Source and publish data:

Tetrahedron p. 10983 - 10992 (1997)

Update date:2022-08-02

Topics:

Authors:

Maligres, Peter E.

Houpis, Ioannis

Rossen, Kai

Molina, Audrey

Sager, Jess

Upadhyay, Veena

Wells, Kenneth M.

Reamer, Robert A.

Lynch, Joseph E.

Askin, David

Volante Volante

Reider, Paul J.

Houghton, Peter

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Article abstract of DOI:10.1016/S0040-4020(97)00359-1

The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall yield from isonipecotic acid 3.

Full text of DOI:10.1016/S0040-4020(97)00359-1

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Product name:benzyl 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]-1‘-carboxylate

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