Reaction of active methylene compounds with α-fluoroalkyl ketones or esters: A convenient synthesis of 4-trifluoromethylpyridines and meta-trifluoromethylphenols

Article abstract of DOI:10.1055/s-1996-4393

The reaction of α-fluoroalkyl ketones 1 or ethyl α-fluoroalkylacetates 2 with active methylene compounds such as methyl acetoacetate (3), acetylacetone (4) and diethyl malonate (5) produced unsaturated fluoroalkyl-containing 1,5-dicarbonyl compounds 6, fr