Reaction of active methylene compounds with α-fluoroalkyl ketones or esters: A convenient synthesis of 4-trifluoromethylpyridines and meta-trifluoromethylphenols

DOI: 10.1055/s-1996-4393

Source and publish data:

Synthesis p. 1363 - 1370 (1996)

Update date:2022-08-03

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Authors:

Guan, Hui-Ping

Hu, Chang-Ming

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Article abstract of DOI:10.1055/s-1996-4393

The reaction of α-fluoroalkyl ketones 1 or ethyl α-fluoroalkylacetates 2 with active methylene compounds such as methyl acetoacetate (3), acetylacetone (4) and diethyl malonate (5) produced unsaturated fluoroalkyl-containing 1,5-dicarbonyl compounds 6, fr

Full text of DOI:10.1055/s-1996-4393

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