Synthesis and renin inhibitory activity of novel angiotensinogen transition state analogues modified at the P2-histidine position

Article abstract of DOI:10.1016/0223-5234(96)83977-8

With the aim of finding new renin inhibitors with improved bioavailability properties, two angiotensinogen transition state analogues 1a and 1b, containing a novel unnatural amino acid at the P₂ position, namely the (2R,3S)- and (2S,3S)-2-amino