A versatile synthesis of amidines from nitriles via amidoximes

Article abstract of DOI:10.1080/00397919608003838

Benzamidines were prepared conveniently from benzonitriles in good yield via catalytic hydrogenation of intermediate benzamidoximes in acetic acid/acetic anhydride.

Full text of DOI:10.1080/00397919608003838

This article was downloaded by: [Ohio State University Libraries]
On: 05 May 2012, At: 05:06
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Versatile Synthesis of
Amidines from Nitriles Via
Amidoximes
Brian D. Judkins a , David G. Allen a , Tracey A. Cook
a , Brian Evans a & Tsarina E. Sardharwala a
a Receptor Chemistry Unit, Glaxo Wellcome
Research and Development, Medicines Research
Centre, Gunnels Wood Road, Stevenage, Herts, SG1
2NY
Available online: 23 Aug 2006
To cite this article: Brian D. Judkins, David G. Allen, Tracey A. Cook, Brian Evans
& Tsarina E. Sardharwala (1996): A Versatile Synthesis of Amidines from Nitriles
Via Amidoximes, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 26:23, 4351-4367
To link to this article: http://dx.doi.org/10.1080/00397919608003838
PLEASE SCROLL DOWN FOR ARTICLE
Full terms and conditions of use: http://www.tandfonline.com/page/terms-
and-conditions
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,

sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden.
The publisher does not give any warranty express or implied or make any
representation that the contents will be complete or accurate or up to
date. The accuracy of any instructions, formulae, and drug doses should be
independently verified with primary sources. The publisher shall not be liable
for any loss, actions, claims, proceedings, demand, or costs or damages
whatsoever or howsoever caused arising directly or indirectly in connection
with or arising out of the use of this material.