Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors

Article abstract of DOI:10.1016/j.cclet.2011.11.017

A short and efficient synthesis of (Z)-2-substituted-5-(4-((2-substitued-5- oxoimidazolidin-4-ylidene)methyl)benzamido)benzoic acid derivatives (8a-g) as potential type of FabH inhibitors is described. Their structures were confirmed by MS, NOE and ¹H NMR.