An enantioselective total synthesis of (+)-cassiol

Article abstract of DOI:10.1016/S0040-4039(96)02191-0

An enantioselective total synthesis of (+)-cassiol 1 possessing potent antiulcerogenic activity has been accomplished by using an efficient construction methodology of the asymmetric quaternary carbon center via a highly diastereoselective intramolecular [3+2] dipolar cycloaddition reaction of the nitrile oxide 10 as a key step.