Bioorganic and Medicinal Chemistry Letters p. 2651 - 2656 (1996)
Update date:2022-08-03
Topics:
Raju
Wu, Chengde
Kois, Adam
Verner, Erik
Okun, Ilya
Stavros, Fiona
Chan, Ming Fai
The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ET(A) selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 μM to ET(A) and ET(B) receptors, respectively.
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Doi:10.1021/acs.orglett.5b01634
(2015)Doi:10.1002/ardp.19963291106
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