Synthesis and biological activities of N,N-dimethyl-2-propen-1-amine derivatives

Article abstract of DOI:10.1016/S0223-5234(97)89856-X

The synthesis of several 3-(4'-bromo<1,1'-biphenyl>-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described.These compounds are potential trypanocide agents with relative low acute toxicities. the inhibition of growth of Escherichia coli by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated. - Keywords: Chagas's disease; trypanocide; Trypanosoma cruzi; aminopropene.