European Journal of Medicinal Chemistry p. 915 - 918 (1996)
Update date:2022-09-26
Topics:
Conti, R. De
Gimenez, S. M. N.
Haun, M.
Pilli, R. A.
Castro, S. L. De
Duran, N.
The synthesis of several 3-(4'-bromo<1,1'-biphenyl>-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described.These compounds are potential trypanocide agents with relative low acute toxicities. the inhibition of growth of Escherichia coli by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated. - Keywords: Chagas's disease; trypanocide; Trypanosoma cruzi; aminopropene.
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