Synthetic studies on halichondrins: A practical synthesis of the C.1-C.13 segment

DOI: 10.1016/S0040-4039(96)01999-5

Source and publish data:

Tetrahedron Letters p. 8643 - 8646 (1996)

Update date:2022-08-05

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Authors:

Stamos, Dean P.

Kishi, Yoshito

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Article abstract of DOI:10.1016/S0040-4039(96)01999-5

A practical, scalable synthesis of the C.1-C.13 segment of halichondrin B has been developed starting from L-mannonic-γ-lactone, using C-allylation/oxy-Michael cyclization and Ni(II)/Cr(II)-mediated vinyltrimethylsilane addition to set the C.6/C.3 and C.11 stereocenters, respectively.

Full text of DOI:10.1016/S0040-4039(96)01999-5

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