Concise synthesis of taxol A-ring components: Remote diastereoselective additions of alkenyl lithiums to aldehydes

DOI: 10.1016/S0040-4039(96)02159-4

Source and publish data:

Tetrahedron Letters p. 9139 - 9142 (1996)

Update date:2022-08-02

Topics:

Authors:

Frost, Christopher

Linnane, Patrick

Magnus, Philip

Spyvee, Mark

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Article abstract of DOI:10.1016/S0040-4039(96)02159-4

The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to aldehydes; 7 is also readily elaborated into the acetal 10.

Full text of DOI:10.1016/S0040-4039(96)02159-4

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