Bioorganic and Medicinal Chemistry Letters p. 2647 - 2650 (1996)
Update date:2022-08-03
Topics:
Hirose, Ryoji
Hamamichi, Norimitsu
Kitao, Yuuki
Matsuzaki, Tohru
Chiba, Kenji
Fujita, Tetsuro
The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)-isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.
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(1996)
