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2-Aminoalcohol immunosuppressants: Structure-activity relationships

DOI: 10.1016/S0960-894X(96)00487-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2647 - 2650 (1996)

Update date:2022-08-03

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Authors:

Hirose, RyojiHirose, Ryoji

Hamamichi, NorimitsuHamamichi, Norimitsu

Kitao, YuukiKitao, Yuuki

Matsuzaki, TohruMatsuzaki, Tohru

Chiba, KenjiChiba, Kenji

Fujita, TetsuroFujita, Tetsuro

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Article abstract of DOI:10.1016/S0960-894X(96)00487-8

The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)-isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.

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Full text of DOI:10.1016/S0960-894X(96)00487-8

Products guided by the article

Product name:Carbamic acid, [1-[[(4-methoxyphenyl)methoxy]methyl]-2-nonadecenyl]-, 1,1-dimethylethyl ester, (S)-

Cas No:185944-57-4

185944-57-4

R&D Labs maybe for 185944-57-4

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