2-Aminoalcohol immunosuppressants: Structure-activity relationships

Article abstract of DOI:10.1016/S0960-894X(96)00487-8

The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)-isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.