2-Aminoalcohol immunosuppressants: Structure-activity relationships

DOI: 10.1016/S0960-894X(96)00487-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2647 - 2650 (1996)

Update date:2022-08-03

Topics:

Authors:

Hirose, Ryoji

Hamamichi, Norimitsu

Kitao, Yuuki

Matsuzaki, Tohru

Chiba, Kenji

Fujita, Tetsuro

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Article abstract of DOI:10.1016/S0960-894X(96)00487-8

The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)-isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.

Full text of DOI:10.1016/S0960-894X(96)00487-8

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