Bicyclization of enynes using the Cp2TiCl2-Mg-BTC system: A practical method to bicyclic cyclopentenones

DOI: 10.1021/jo9810718

Source and publish data:

Journal of Organic Chemistry p. 9285 - 9291 (1998)

Update date:2022-09-26

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Authors:

Zhao, Zongbao

Ding, Yu

Zhao, Gang

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Article abstract of DOI:10.1021/jo9810718

Bicyclic titanacycles 2 generated with the Cp₂TiCl₂-Mg-P(OEt)₃ system can be trapped with bis(trichloromethyl) carbonate (BTC) to give bicyclic cyclopentenones 3 in good yields. The titanacycle 2m was isolated and well- identified. Bicyclization of enynes containing 1,2-disubstituted olefin by this method gave good results with excellent stereoselectivity.

Full text of DOI:10.1021/jo9810718

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