Enantioselective synthesis of medium-ring sub-units of brevetoxin A by ring-closing metathesis

Article abstract of DOI:10.1016/S0040-4039(96)02233-2

A new strategy for the enantioselective synthesis of eight- and nine-membered cyclic ethers corresponding to sub-units of brevetoxin A has been developed. The strategy involves the use of ring-closing metathesis reactions of allylic ethers to effect ring construction.