An enantioselective synthesis of cyclopentyl-l-aspartic acid amenable to large scale

DOI: 10.1055/s-1997-1518

Source and publish data:

Synthesis p. 32 - 34 (1997)

Update date:2022-08-03

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Authors:

Moss, Neil

Ferland, Jean-Marie

Goulet, Sylvie

Guse, Ingrid

Malenfant, Eric

Plamondon, Louis

Plante, Raymond

Déziel, Robert

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Article abstract of DOI:10.1055/s-1997-1518

A new enantioselective synthesis of cyclopentyl-L-aspartic acid [(S)α-amino-1-(carboxy)cyclopentaneacetic acid] (1) and its N-Boc derivative 2 has been developed. This synthesis is amenable to kilogram scale preparation and avoids low temperature reactions and column chromatography.

Full text of DOI:10.1055/s-1997-1518

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Product name:1-[(S)-Cyano-((S)-1-phenyl-ethylamino)-methyl]-cyclopentanecarboxylic acid methyl ester

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