Stereocontrolled synthesis of C10-C22 fragment of the immunosuppressant FK 506. An occurrence of complementary stereoselectivity in the C15 ketone reduction

DOI: 10.1016/S0957-4166(96)00445-4

Source and publish data:

Tetrahedron Asymmetry p. 3371 - 3390 (1996)

Update date:2022-07-30

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Authors:

Morimoto, Yoshiki

Mikami, Atsushi

Kuwabe, Shin-Itsu

Shirahama, Haruhisa

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Article abstract of DOI:10.1016/S0957-4166(96)00445-4

The stereoselective syntheses of the C10-C22 fragment 2a and its C15-epimer 2b of the immunosuppressant FK 506 1 have been carried out through convergent coupling of the sulfone 3, which could be constructed by highly stereocontrolled ester-enolate Claise

Full text of DOI:10.1016/S0957-4166(96)00445-4

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