Synthesis of the C(1)-C(9) segment of the cytotoxic macrolides epothilon A and B

DOI: 10.1016/S0040-4039(96)02156-9

Source and publish data:

Tetrahedron Letters p. 9179 - 9182 (1996)

Update date:2022-07-29

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Authors:

Mulzer, Johann

Mantoulidis, Andreas

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Article abstract of DOI:10.1016/S0040-4039(96)02156-9

The C(1)-C(9) segment 3 of the macrolides epothilon A and B 1, two new cytotoxic natural products, has been synthesized in a direct manner. Key steps in the synthesis are a stereoselective aldol reaction of 6 and 7 and a Brown allylation of 9.

Full text of DOI:10.1016/S0040-4039(96)02156-9

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