Synthesis of sulfo and sialyl Lewis(x) analogs with a mannose at the reducing end

DOI: 10.1016/S0960-894X(97)00181-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1157 - 1160 (1997)

Update date:2022-09-26

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Authors:

Huang, Bao-Guo

Locke, Robert D.

Jain, Rakesh K.

Matta, Khushi L.

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Article abstract of DOI:10.1016/S0960-894X(97)00181-9

Stereoselective syntheses of 3-O-sulfo and 3-O-sialyl Lewis(x) analogs 1 and 2 were accomplished. Compound 1 showed greater inhibitory activity than the natural ligand sialyl Lewis(x) against P and L-selectin.

Full text of DOI:10.1016/S0960-894X(97)00181-9

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