Heterocycles p. 77 - 85 (1997)
Update date:2022-07-30
Topics:
Chou, Shan-Yen
Chen, Shyh-Fong
A synthesis of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine, a key intermediate for the preparation of gastric acid inhibiting compound omeprazole, is described. The procedure consists of preparation of pyrone, pyridone and pyridine derivatives sequentially.
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