Bioorganic and Medicinal Chemistry Letters p. 279 - 284 (1999)
Update date:2022-07-29
Topics:
Elliott, John T.
Hoekstra, William J.
Maryanoff, Bruce E.
Prestwich, Glenn D.
Photoactivatable analogs of the human thrombin receptor (PAR-1) antagonist, N-trans-cinnamoyl-p-fluoroPhe-p-guandinoPhe-Leu-Arg-NH2 (BMS- 197525), were prepared with benzophenone substitutions in the N-terminal, Leu, or Arg position. The analogs retained antagonist activity (with reduced potency); the tritium-labeled isotopomers are potential photoaffinity labels for the receptor. C-Terminal extension of the analogs with ornithine(biotin) did not significantly alter antagonist potency.
View MoreHangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Alpha(shijiazhuang) Chemical Co., Ltd
Contact:+86-311-85652680
Address:Shijiazhuang City ,Hebei Province China
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-18051083338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Changzhou naidechemical Co.Ltd
Contact:+86-519-82589807
Address:NO.25,Houyang street,Jintan,Changzhou City
Shanghai PuYi Chem-Tech Co.,Ltd.
Contact:+86-21-57687505-227
Address:3 Floor, Building 11, No 201 MinYi Road, Songjiang District, Shanghai 201612, China
Doi:10.1016/j.ejmech.2015.12.004
(2016)Doi:10.1002/anie.200903334
(2009)Doi:10.1016/j.tet.2009.07.097
(2009)Doi:10.1021/ja907252u
(2009)Doi:10.1039/d1sc01300a
(2021)Doi:10.1055/s-1988-27558
(1988)