Convenient synthesis of N-(2,2-dimethyl-1,3-dioxan-5-yl)-1H-indazole-3-carboxamide, the intermediate of 5-HT3 receptor antagonist

Article abstract of DOI:10.1080/00397919708003326

The convenient large-scale synthesis of the title compound, which is the intermediate of potent 5-HT₃ receptor antagonist, N-(1-benzyl)-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3 carboxamide (1), is described.

Full text of DOI:10.1080/00397919708003326

This article was downloaded by: [University of Arizona]
On: 06 December 2012, At: 05:33
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number:
1072954 Registered office: Mortimer House, 37-41 Mortimer Street,
London W1T 3JH, UK
Synthetic Communications:
An International Journal
for Rapid Communication of
Synthetic Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
Convenient Synthesis
of N-(2, 2-Dimethyl-1,
3-dioxan-5-yl)-1H-
indazole-3-carboxamide,
the Intermediate of 5-HT3
Receptor Antagonist
Toshiya Morie a , Hiroshi Harada a & Shiro Kato a
a Discovery Research Laboratories I, Dainippon
Pharmaceutical Co., Ltd., Enoki 33-94, Suita,
Osaka, 564, Japan
Version of record first published: 20 Aug 2006.
To cite this article: Toshiya Morie, Hiroshi Harada & Shiro Kato (1997):
Convenient Synthesis of N-(2, 2-Dimethyl-1, 3-dioxan-5-yl)-1H-indazole-3-
carboxamide, the Intermediate of 5-HT3 Receptor Antagonist, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 27:4, 559-566
To link to this article: http://dx.doi.org/10.1080/00397919708003326
PLEASE SCROLL DOWN FOR ARTICLE
Full terms and conditions of use: http://www.tandfonline.com/page/
terms-and-conditions

This article may be used for research, teaching, and private study
purposes. Any substantial or systematic reproduction, redistribution,
reselling, loan, sub-licensing, systematic supply, or distribution in any
form to anyone is expressly forbidden.
The publisher does not give any warranty express or implied or make
any representation that the contents will be complete or accurate or
up to date. The accuracy of any instructions, formulae, and drug doses
should be independently verified with primary sources. The publisher
shall not be liable for any loss, actions, claims, proceedings, demand, or
costs or damages whatsoever or howsoever caused arising directly or
indirectly in connection with or arising out of the use of this material.