A chemo-enzymatic synthesis of the N-terminal aminoacid lactone of Nikkomycin B

DOI: 10.1016/S0957-4166(96)00507-1

Source and publish data:

Tetrahedron Asymmetry p. 245 - 251 (1997)

Update date:2022-07-30

Topics:

Authors:

Kapeller

Jary Jary

Hayden Hayden

Griengl Griengl

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Article abstract of DOI:10.1016/S0957-4166(96)00507-1

(2S,3S,4S)-4-(4-Acetoxyphenyl)-2-amino-3-methylbutan-4-olide (S,S,S)-11, a precursor for the aminoacid part of Nikkomycin B, was prepared in a five step synthesis in 12% yield, involving two enzymatic steps. First enantiopurity was achieved by resolution

Full text of DOI:10.1016/S0957-4166(96)00507-1

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