A chemo-enzymatic synthesis of the N-terminal aminoacid lactone of Nikkomycin B

Article abstract of DOI:10.1016/S0957-4166(96)00507-1

(2S,3S,4S)-4-(4-Acetoxyphenyl)-2-amino-3-methylbutan-4-olide (S,S,S)-11, a precursor for the aminoacid part of Nikkomycin B, was prepared in a five step synthesis in 12% yield, involving two enzymatic steps. First enantiopurity was achieved by resolution