Tetrahedron Letters p. 1129 - 1132 (1997)
Update date:2022-08-04
Topics:
Sledeski, Adam W.
O'Brien, Michael K.
Truesdale, Larry K.
An efficient, convergent synthesis of an LTD4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.
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(1997)
