Studies on the active conformation of the NK1 antagonist CGP 49823. Part 2. Fluoro-olefin analogs of tertiary amide rotamers

DOI: 10.1016/S0960-894X(96)00624-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 351 - 354 (1997)

Update date:2022-09-26

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Authors:

Veenstra, Siem J.

Hauser, Kathleen

Felber, Peter

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Article abstract of DOI:10.1016/S0960-894X(96)00624-5

Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding affinities for the NK₁ receptor suggests an active conformation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent.

Full text of DOI:10.1016/S0960-894X(96)00624-5

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