Introduction of organometallic fragments into α-amino acids by reactions of α-bromoglycine derivatives with anionic organotransition-metal compounds

DOI: 10.1002/cber.19971300206

Source and publish data:

Chemische Berichte p. 171 - 177 (1997)

Update date:2022-08-03

Topics:

Authors:

Kayser, Bernd

Polborn, Kurt

Steglich, Wolfgang

Beck, Wolfgang

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Article abstract of DOI:10.1002/cber.19971300206

The reactions of protected cc-bromoglycine esters R'lOlCNHCHtBrJCO₂R² (R¹ = Ph, OCMe₃; R² = Me, JBu) with organometallic anions of acetylferrocene, CpFe(CO)(PPh₃)-C(O)CH₃, (OC)₅M=C(OMe)CH₃ (M = Cr, W), (OC)₃Cr(η⁶-diphenylmethane), (OC)₃Cr(η⁶-fluorene), (OC)₃Cr(η⁶-dihydroanthracene) and of (OC)₃Cr(η⁶-aniline) and (OC)³Cr(η⁶-o-toluidine) provide a method for the introduction of organometallic fragments into the side chains of α-amino acids. The complexes may be useful as markers for α-amino acids in peptides. The compound (OC)₃Cr(η⁶-o-C₆H₄(CH ₃)NHC-(H)(CO₂Me)NHC(O)Ph was characterized by X-ray diffraction. VCH Verlaegsgesellschaft mbH,.

Full text of DOI:10.1002/cber.19971300206

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