Introduction of organometallic fragments into α-amino acids by reactions of α-bromoglycine derivatives with anionic organotransition-metal compounds

Article abstract of DOI:10.1002/cber.19971300206

The reactions of protected cc-bromoglycine esters R'lOlCNHCHtBrJCO₂R² (R¹ = Ph, OCMe₃; R² = Me, JBu) with organometallic anions of acetylferrocene, CpFe(CO)(PPh₃)-C(O)CH₃, (OC)₅M=C(OMe)CH₃ (M = Cr, W), (OC)₃Cr(η⁶-diphenylmethane), (OC)₃Cr(η⁶-fluorene), (OC)₃Cr(η⁶-dihydroanthracene) and of (OC)₃Cr(η⁶-aniline) and (OC)³Cr(η⁶-o-toluidine) provide a method for the introduction of organometallic fragments into the side chains of α-amino acids. The complexes may be useful as markers for α-amino acids in peptides. The compound (OC)₃Cr(η⁶-o-C₆H₄(CH ₃)NHC-(H)(CO₂Me)NHC(O)Ph was characterized by X-ray diffraction. VCH Verlaegsgesellschaft mbH,.