Bioorganic and Medicinal Chemistry Letters p. 515 - 520 (1997)
Update date:2022-08-03
Topics:
Kitani, Hiroyuki
Kuroda, Tsuyoshi
Moriguchi, Akihiko
Ao, Hideki
Hirayama, Fumihiro
Ikeda, Yoshifumi
Kawakita, Takeshi
A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because of being most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability.
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