Synthesis and structural optimization of 7-(3,3-disubstituted-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8 -methoxy-4-oxo-3-quinolinecarboxylic acids as antibacterial agents

DOI: 10.1016/S0960-894X(97)00054-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 515 - 520 (1997)

Update date:2022-08-03

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Authors:

Kitani, Hiroyuki

Kuroda, Tsuyoshi

Moriguchi, Akihiko

Ao, Hideki

Hirayama, Fumihiro

Ikeda, Yoshifumi

Kawakita, Takeshi

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Article abstract of DOI:10.1016/S0960-894X(97)00054-1

A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because of being most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability.

Full text of DOI:10.1016/S0960-894X(97)00054-1

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