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Chemoenzymatic synthesis of Galα1-3Gal, Galα1-3Galβ1-4GlcNAc, and their PEG-conjugates

DOI: 10.1016/S0960-894X(97)00017-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 255 - 258 (1997)

Update date:2022-07-30

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Authors:

Matsuo, IchiroMatsuo, Ichiro

Fujimoto, HiroshiFujimoto, Hiroshi

Isomura, MegumiIsomura, Megumi

Ajisaka, KatsumiAjisaka, Katsumi

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Article abstract of DOI:10.1016/S0960-894X(97)00017-6

Galα1-3Gal-pNP was prepared enzymatically from Gal-pNP using α-galactosidase from coffee beans. PEG was attached after the reduction of nitro group into amino group to give Galα1-3Gal-PEG conjugate. After removing the pNP group in Galα1-3Gal-pNP, the obtained disaccharide was used for the synthesis of Galα1-3Galβ1-4GlcNAc and corresponding trisaccharide-PEG conjugate.

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Full text of DOI:10.1016/S0960-894X(97)00017-6

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Product name:Acetic acid (2R,3R,4S,5S,6R)-5-acetoxy-6-acetoxymethyl-2-(4-acetylamino-phenoxy)-4-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester

Cas No:188302-05-8

188302-05-8

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