Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs

DOI: 10.1016/S0960-894X(96)00623-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 347 - 350 (1997)

Update date:2022-08-04

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Authors:

Veenstra, Siem J.

Hauser, Kathleen

Betschart, Claudia

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Article abstract of DOI:10.1016/S0960-894X(96)00623-3

Five conformationally restricted analogs of CGP 49823 have been synthesized. Comparison of their in vitro activities indicates an active conformation of CGP 49823 in which the two aromatic rings of the benzyl and the benzoyl groups are in proximity of each other.

Full text of DOI:10.1016/S0960-894X(96)00623-3

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