Palladium (0) catalyzed nucleophilic substitution on 2-cyclopropylidene-phenoxy ethanes

Article abstract of DOI:10.1080/00397919708004192

2-cyclopropylidene-phenoxy ethanes 5, 2-substituted with alkyl, aryl or heterocyclic groups are readily obtained in high yields by the Wittig reaction of the easily accessible α-phenoxy etanones 4 with (3-bromo propyl) triphenylphosphonium bromide. They react with complete regioselectivity in palladium (0) catalyzed nucleophilic substitutions with a series of soft carbon nucleophiles giving an easy entry to 5,6-methanoamino acids.

Full text of DOI:10.1080/00397919708004192

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Palladium (0) Catalyzed
Nucleophilic Substitution On
2-Cyclopropylidene-phenoxy
Ethanes
Angela M. Bernard a & Pier P. Piras a
a Dipartimento di Scienze Chimiche
dell'Università di Cagliari , Via Ospedale 72,
Cagliari, 09100, Italy
Published online: 22 Aug 2006.
To cite this article: Angela M. Bernard & Pier P. Piras (1997) Palladium (0)
Catalyzed Nucleophilic Substitution On 2-Cyclopropylidene-phenoxy Ethanes,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 27:5, 709-723, DOI: 10.1080/00397919708004192
To link to this article: http://dx.doi.org/10.1080/00397919708004192
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