Synthesis of 2-azabicyclo[3.3.1]lnonanes by means of (carbamoyl)dichloromethyl radical cyclization

Article abstract of DOI:10.1016/S0040-4020(96)01051-4

A new procedure for the synthesis of 2-azabicyclo[3.3.1]nonanes by intramolecular carboradical cyclization of 4-(trichloroacetamido)cyclohexenes substituted with an electron withdrawing substituent tester or nitrile) is described. The procedure allows the preparation of synthetically interesting azabicyclos 14 and 15 in nearly 70% yield.