A Short Synthesis of the Factor-Xa Inhibitor DX-9065a Using Palladium-Catalyzed Key Steps1

DOI: 10.1002/hlca.19970800322

Source and publish data:

Helvetica Chimica Acta p. 892 - 896 (1997)

Update date:2022-08-04

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Authors:

Kehr, Christiane

Neidlein, Richard

Engh, Richard A.

Brandstetter, Hans

Kucznierz, Ralf

Leinert, Herbert

Marzenell, Klaus

Strein, Klaus

Von Der Saal, Wolfgang

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Article abstract of DOI:10.1002/hlca.19970800322

We describe a new, efficient synthesis of DX-9065a (4), a potent inhibitor of the blood coagulation enzyme factor Xa (fXa) which has previously been prepared in more than 20 steps. We saved approximately 10 steps starting with a Pd-catalyzed cyanation of

Full text of DOI:10.1002/hlca.19970800322

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