Helvetica Chimica Acta p. 892 - 896 (1997)
Update date:2022-08-04
Topics:
Kehr, Christiane
Neidlein, Richard
Engh, Richard A.
Brandstetter, Hans
Kucznierz, Ralf
Leinert, Herbert
Marzenell, Klaus
Strein, Klaus
Von Der Saal, Wolfgang
We describe a new, efficient synthesis of DX-9065a (4), a potent inhibitor of the blood coagulation enzyme factor Xa (fXa) which has previously been prepared in more than 20 steps. We saved approximately 10 steps starting with a Pd-catalyzed cyanation of
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Doi:10.1021/acs.jmedchem.5b00115
(2015)Doi:10.1021/ja963416e
(1997)Doi:10.1016/S0040-4020(98)00932-6
(1998)Doi:10.1016/S0022-328X(00)84177-7
(1966)Doi:10.1021/jo961089n
(1997)Doi:10.1021/jo00835a071
(1970)
