A Simple Method for the Synthesis of 2'-O-Alkylguanosine Derivatives

Article abstract of DOI:10.1016/S0960-894X(97)00024-3

A new synthetic route has been devised for the preparation of 2'-O-alkyl guanosine derivatives. Utilizing a strategy of minimal protection, the alkylation was performed on partly protected guanosine using an alkyl halide and a sterically hindered strong organic base.