Convenient chemoenzymatic synthesis of β-purine-diphosphate sugars (GDP-fucose-analogues)

Article abstract of DOI:10.1016/S0968-0896(96)00258-1

A series of peracetylated β-sugar-1-phosphates with L-fuco configuration are efficiently prepared chemically and coupled in high yields to purine monophosphate bases via imidazolide activation. The resulting purine diphosphate sugars are deacetylated comp