Bioorganic and Medicinal Chemistry Letters p. 1403 - 1408 (1999)
Update date:2022-08-03
Topics:
Gueller, Rolf
Binggeli, Alfred
Breu, Volker
Bur, Daniel
Fischli, Walter
Hirth, Georges
Jenny, Christian
Kansy, Manfred
Montavon, Francois
Mueller, Marcel
Oefner, Christian
Stadler, Heinz
Vieira, Eric
Wilhelm, Maurice
Wostl, Wolfgang
Maerki, Hans Peter
Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D((pH 7.4)) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.
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Doi:10.1021/ja106470x
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