Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase

DOI: 10.1016/S0960-894X(97)00061-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 505 - 510 (1997)

Update date:2022-07-30

Topics:

Authors:

Chen, Shoujun

Lin, Chun-Hung

Walsh, Christopher T.

Coward, James K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00061-9

A phosphinate analog of glutathionyl spermidine (Gsp), 3, has been synthesized and evaluated as an inhibitor of Gsp synthetase (GSPS). In addition, a non-spermidine-containing derivative (4) was synthesized in order to evaluate the role of the polyamine m

Full text of DOI:10.1016/S0960-894X(97)00061-9

Products guided by the article

Product name:{4-[[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-(2,2,2-trifluoro-acetyl)-amino]-butyl}-[(trityl-amino)-methyl]-phosphinic acid ethyl ester

Cas No:188966-02-1

R&D Labs maybe for 188966-02-1

Zibo Shiji Zhonglian Pharmaceutical Technology Co., Ltd.

Contact:+86-533-3075187

Address:66 Xin'er Road, Linzi District, Zibo City, Shandong, China
N&R INDUSTRIES,INC

Contact:Tel:+86-29-88764861 Fax:+86-29-88764861

Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
SHIJIAZHUANG HENRYTE CHEMICALS CO,.LTD(expird)

Contact:+86-311-85208698 311-80837698

Address:NO.166, yuhua west road, SHIJIAZHUANG, China
Shanghai Maxchemco Chemical Industry Co., Ltd.

Contact:(86)21-51079223

Address:No.1305-8, B241, the Ecust Park, Huajing Road, Xuhui District, Shanghai
SHIJIAZHUANG HENRYTE CHEMICALS CO,.LTD(expird)

Contact:+86-311-85208698 311-80837698

Address:NO.166, yuhua west road, SHIJIAZHUANG, China

Relevant to this article

A New method of synthesizing phenalen-1-one: Reduction of 3-hydroxyphenalen-1-one using nabh4 and lanthanoid chlorides

Doi:10.1080/00397910902883546
(2009)
Allylcarbinyl-Cyclopropylcarbinyl Rearrangement

Doi:10.1021/ja00525a051
(1980)
1,6-Epithio- and 1,6-Episeleno-β-D-glucopyranose: Useful Adjuncts in the Synthesis of 6-Deoxy-β-D-glucopyranosides

Doi:10.1071/CH99009
(1999)
Synthesis and spectral properties of [3-(heptyloxy)phenoxy]acetic acid and its derived meso-sibstituted tetrabenzoporphyrins

Doi:10.1134/S1070363208090259
(2008)
N-carbamoyl analogs of Zafirlukast: Potent receptor antagonists of leukotriene D₄

Doi:10.1016/S0960-894X(98)00442-9
(1998)
Organoelement substituted ammonia salts. Crystal structures of [HN(SnMe₃)₃]I, [H₂N(SnMe₃)₂][SnMe₃Cl₂], and [N(AsMe₃)₂]Br

Doi:10.1002/zaac.199762301107
(1997)

Article Doi