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Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase

DOI: 10.1016/S0960-894X(97)00061-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 505 - 510 (1997)

Update date:2022-07-30

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Authors:

Chen, ShoujunChen, Shoujun

Lin, Chun-HungLin, Chun-Hung

Walsh, Christopher T.Walsh, Christopher T.

Coward, James K.Coward, James K.

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Article abstract of DOI:10.1016/S0960-894X(97)00061-9

A phosphinate analog of glutathionyl spermidine (Gsp), 3, has been synthesized and evaluated as an inhibitor of Gsp synthetase (GSPS). In addition, a non-spermidine-containing derivative (4) was synthesized in order to evaluate the role of the polyamine m

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Full text of DOI:10.1016/S0960-894X(97)00061-9

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Product name:{4-[[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-(2,2,2-trifluoro-acetyl)-amino]-butyl}-[(trityl-amino)-methyl]-phosphinic acid ethyl ester

Cas No:188966-02-1

188966-02-1

R&D Labs maybe for 188966-02-1

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