Synthesis and preliminary in vitro evaluation of a new memantine derivative 1-amino-3-[18F]fluoromethyl-5-methyl-adamantane: A potential ligand for mapping the N-methyl-D-aspartate receptor complex

DOI: 10.1002/(SICI)1099-1344(199703)39:3<241::AID-JLCR966>3.0.CO;2-V

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 241 - 250 (1997)

Update date:2022-07-30

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Authors:

Samnick, Samuel

Ametamey, Simon

Gold, Markus R.

Schubiger, Pius A.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199703)39:3<241::AID-JLCR966>3.0.CO;2-V

The new memantine derivative 1-amino-3-[¹⁸F]fluoromethyl-5-methyl-adamantane (¹⁸F-MEM) was prepared in a two-step reaction sequence for evaluation as a PET tracer. This involves the no-carrier-added nucleophilic radiofluorination of

Full text of DOI:10.1002/(SICI)1099-1344(199703)39:3<241::AID-JLCR966>3.0.CO;2-V

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Product name:1-[N-(tert-butyloxy)carbamoyl]-3-(tosyl)methyl-5-methyl-adamantane

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