Syntheses of novel chiral 2,5-dialkyl-7-azabicyclo[2.2.1]heptanes and 2,5-dialkyl-7-thiobicyclo[2.2.1]heptanes

Article abstract of DOI:10.1016/S0040-4039(98)00989-7

New C₂-symmetric chiral amines with a rigid bicyclic framework have been synthesized via hydrogenation of monoazides catalyzed by 5% Pd/C in methanol. Enantiomerically pure 2,5-dialkyl-7-thiobicyclo[2.2.1]heptanes were made from readily available materials.