Tetrahedron p. 8827 - 8840 (1998)
Update date:2022-08-03
Topics:
Palmer, Matthew J.
Studley, John R.
Walsgrove, Tim C.
Wills, Martin
The phosphinamide N-protecting group is demonstrated to be an effective directing group for diastereoselective reductions of proximal ketones. A range of methods for the preparation of the requisite α-amino ketones substrates are described.
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