The use of phosphinamide N-protecting groups in the diastereoselective reduction of ketones

DOI: 10.1016/S0040-4020(98)00474-8

Source and publish data:

Tetrahedron p. 8827 - 8840 (1998)

Update date:2022-08-03

Topics:

Authors:

Palmer, Matthew J.

Studley, John R.

Walsgrove, Tim C.

Wills, Martin

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Article abstract of DOI:10.1016/S0040-4020(98)00474-8

The phosphinamide N-protecting group is demonstrated to be an effective directing group for diastereoselective reductions of proximal ketones. A range of methods for the preparation of the requisite α-amino ketones substrates are described.

Full text of DOI:10.1016/S0040-4020(98)00474-8

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