Studies on cardiac ingredients of plants. XIII: Chemical modification of gitoxin to cardiotonic compounds without vascular contractile effect

DOI: 10.1248/cpb.45.599

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 599 - 607 (1997)

Update date:2022-08-03

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Authors:

Nagatsu, Akito

Nakamura, Yukitaka

Takemoto, Kouya

Shibatomi, Kazutaka

Nagai, Shin-Ichi

Ueda, Taisei

Sakakibara, Jinsaku

Hidaka, Hiroyoshi

Fujita, Michiko

Hotta, Yoshihiro

Takeya, Kazumi

Asano, Masahisa

Hashimoto, Toshihiro

Asakawa, Yoshinori

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Article abstract of DOI:10.1248/cpb.45.599

Nitrated gitoxins (4) and bufotoxin homologues with various lengths of alkyl chain at C-3 of the steroid nucleus (10) were prepared from gitoxin (1). The pharmacological activities of the resulting compounds (4 and 10) were evaluated by measurement of inh

Full text of DOI:10.1248/cpb.45.599

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