An asymmetric synthesis of the ABC ring system of 8-demethyltaxoids from optically active 8-membered ring compound via intramolecular aldol and pinacol coupling reactions

DOI: 10.1246/cl.1997.419

Source and publish data:

Chemistry Letters p. 419 - 420 (1997)

Update date:2022-08-04

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Authors:

Shiina, Isamu

Nishimura, Toshihiro

Ohkawa, Naoto

Sakoh, Hiroki

Nishimura, Koji

Saitoh, Katsuyuki

Mukaiyama, Teruaki

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Article abstract of DOI:10.1246/cl.1997.419

Optically active novel taxoids were efficiently synthesized from 8-membered ring compound 3 by successive constructions of BC and ABC ring systems via each intramolecular aldol and intramolecular pinacol coupling reactions.

Full text of DOI:10.1246/cl.1997.419

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Product name:(3aS,6aS,7S,8S,10R,11R,11aS,11bS)-8-Allyl-7,11-bis-benzyloxy-2,2,9,9-tetramethyl-6-methylene-dodecahydro-1,3-dioxa-cycloocta[de]naphthalene-8,10-diol

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