A novel synthesis of a key intermediate for penems and carbapenems utilizing lipase-catalyzed kinetic resolution

Article abstract of DOI:10.1016/0957-4166(96)00132-2

Titanium enolate-mediated aldol reaction of N-phthaloyl-β-alanyl-1,3-benzoxazinone 5 with acetaldehyde gave the (±)-syn-aldol (±)-6 in a high yield with high diastereoselectivity. Lipase-catalyzed hydrolysis of the corresponding laurate (±)-7b furnished e